Vaiserman A, Krasnienkov D. Telomere length as a marker of biological age: state-of-the-art, open issues, and future perspectives. Front Genet. 2021; 11: 1816.
Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, et al. Association between telomere length and risk of cancer and non-neoplastic diseases: a Mendelian randomization study. JAMA Oncol. 2017; 3: 636–51.
Madrid AS, Rasmussen KL, Rode L, Frikke-Schmidt R, Nordestgaard BG, Bojesen SE. Observational and genetic studies of short telomeres and Alzheimer’s disease in 67,000 and 152,000 individuals: a Mendelian randomization study. Eur J Epidemiol. 2020; 35: 147–56.
Barrett EL, Richardson DS. Sex differences in telomeres and lifespan. Aging Cell. 2011; 10: 913–21.
Diez Roux AV, Ranjit N, Jenny NS, Shea S, Cushman M, Fitzpatrick A, et al. Race / ethnicity and telomere length in the Multi-Ethnic Study of Atherosclerosis. Aging Cell. 2009; 8: 251–7.
Lin X, Zhou J, Dong B. Effect of different levels of exercise on telomere length: a systematic review and meta-analysis. J Rehabil Med. 2019; 51: 473–8.
Astuti Y, Wardhana A, Watkins J, Wulaningsih W. Cigarette smoking and telomere length: a systematic review of 84 studies and meta-analysis. Environ Res. 2017; 158: 480–9.
Strandberg TE, Strandberg AY, Saijonmaa O, Tilvis RS, Pitkälä KH, Fyhrquist F. Association between alcohol consumption in healthy midlife and telomere length in older men. The Helsinki Businessmen Study. Eur J Epidemiol. 2012; 27: 815–22.
Weischer M, Bojesen SE, Nordestgaard BG. Telomere shortening unrelated to smoking, body weight, physical activity, and alcohol intake: 4,576 general population individuals with repeat measurements 10 years apart. PLoS Genet. 2014; 10: e1004191.
Dixit S, Whooley MA, Vittinghoff E, Roberts JD, Heckbert SR, Fitzpatrick AL, et al. Alcohol consumption and leukocyte telomere length. Sci Rep. 2019; 9: 1–10.
De Carvalho LM, Wiers CE, Manza P, Sun H, Schwandt M, Wang GJ, et al. Effect of alcohol use disorder on cellular aging. Psychopharmacology. 2019; 236: 3245–55.
Wang H, Kim H, Baik I. Associations of alcohol consumption and alcohol flush reaction with leukocyte telomere length in Korean adults. Nutr Res Pract. 2017; 11: 334–9.
Gelernter J, Polimanti R. Genetics of substance use disorders in the era of big data. Nat Rev Genet. 2021; 22: 712–29.
Davey Smith G, Ebrahim S. ‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol. 2003; 32: 1–22.
O’keefe EL, Dinicolantonio JJ, O’keefe JH, Lavie CJ. Alcohol and CV health: Jekyll and Hyde J-curves. Prog Cardiovascular Dis. 2018; 61: 68–75.
Allen NE, Sudlow C, Peakman T, Collins R. UK biobank data: come and get it. Sci Transl Med. 2014; 6: 22.
Bycroft C, Freeman C, Petkova D, Band G, Elliott LT, Sharp K, et al. The UK Biobank resource with deep phenotyping and genomic data. Nature. 2018; 562: 203–9.
Topiwala A, Ebmeier KP, Maullin-Sapey T, Nichols TE. Alcohol consumption and MRI markers of brain structure and function: cohort study of 25.78 UK Biobank participants. Neuroimage Clin. 2022; 35.
Codd V, Denniff M, Swinfield C, Warner S, Papakonstantinou M, Sheth S, et al. Measurement and initial characterization of leukocyte telomere length in 474,074 participants in UK Biobank. Nat Aging. 2022; 2: 170–9.
Liu M, Jiang Y, Wedow R, Li Y, Brazel DM, Chen F, et al. Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Nat Genet. 2019; 51: 237–44.
Gormley M, Dudding T, Sanderson E, Martin RM, Thomas S, Tyrrell J, et al. A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer. Nat Commun. 2020; 11: 1–10.
Burgess S, Davies NM, Thompson SG. Bias due to participant overlap in two ‐ sample Mendelian randomization. Genet Epidemiol. 2016; 40: 597–608.
Zhou H, Sealock JM, Sanchez-Roige S, Clarke TK, Levey DF, Cheng Z, et al. Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits. Nat Neurosci. 2020; 23: 809–18.
Codd V, Wang Q, Allara E, Musicha C, Kaptoge S, Stoma S, et al. Polygenic basis and biomedical consequences of telomere length variation. Nat Genet. 2021; 53: 1425–33.
Verbanck M, Chen CY, Neale B, Do R. Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nat Genet. 2018; 50: 693–8.
Hemani G, Tilling K, Davey, Smith G. Orienting the causal relationship between imprecisely measured traits using GWAS summary data. PLoS Genet. 2017; 13: e1007081.
Doherty A, Smith-Byrne K, Ferreira T, Holmes MV, Holmes C, Pulit SL, et al. GWAS identifies 14 loci for device-measured physical activity and sleep duration. Nat Commun. 2018; 9: 1-8.
Carvalho AF, Heilig M, Perez A, Probst C, Rehm J. Alcohol use disorders. Lancet. 2019; 394: 781–92.
Kranzler HR, Zhou H, Kember RL, Smith RV, Justice AC, Damrauer S, et al. Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. Nat Commun. 2019; 10: 1–11.
Rosenström T, Torvik FA, Ystrom E, Tchaikovsky NO, Gillespie NA, Aggen SH, et al. Prediction of alcohol use disorder using personality disorder traits: a twin study. Addiction. 2018; 113: 15–24.
Li JJ, Savage JE, Kendler KS, Hickman M, Mahedy L, Macleod J, et al. Polygenic risk, personality dimensions, and adolescent alcohol use problems: a longitudinal study. J Stud Alcohol Drugs. 2017; 78: 442–51.
Polimanti R, Peterson RE, Ong JS, Macgregor S, Edwards AC, Clarke TK, et al. Evidence of causal effect of major depression on alcohol dependence: findings from the psychiatric genomics consortium. Psychol Med. 2019; 49: 1218–26.
Kamper-Jørgensen M, Grønbæk M, Tolstrup J, Becker U. Alcohol and cirrhosis: dose – response or threshold effect? J Hepatol. 2004; 41: 25–30.
Reichert S, Stier A. Does oxidative stress shorten telomeres in vivo? A review. Biol Lett. 2017; 13: 20170463.
Das SK, Vasudevan D. Alcohol-induced oxidative stress. Life Sci. 2007; 81: 177–87.
Koch OR, Pani G, Borrello S, Colavitti R, Cravero A, Farrè S, et al. Oxidative stress and antioxidant defenses in ethanol-induced cell injury. Mol Asp Med. 2004; 25: 191–8.
Colell A, García-Ruiz C, Miranda M, Ardite E, Marí M, Morales A, et al. Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor. Gastroenterology. 1998; 115: 1541–51.
Grant BF. Prevalence and correlates of alcohol use and DSM-IV alcohol dependence in the United States: results of the National Longitudinal Alcohol Epidemiologic Survey. J Stud Alcohol. 1997; 58: 464–73.
Dlouha D, Maluskova J, Lesna IK, Lanska V, Hubacek J. Comparison of the relative telomere length measured in leukocytes and eleven different human tissues. Physiological Res. 2014; 63: S343.